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需求追踪；信息检索；紧密关系；目标制品 1

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Fast removal of ocular artifacts from electroencephalogram signals using spatial constraint independent

Bang-hua YANG,Liang-fei HE,Lin LIN,Qian WANG

《信息与电子工程前沿（英文）》 2015年 第16卷 第6期   页码 486-496 doi: 10.1631/FITEE.1400299

摘要： Ocular artifacts cause the main interfering signals within electroencephalogram (EEG) signal measurements. An adaptive filter based on reference signals from an electrooculogram (EOG) can reduce ocular interference, but collecting EOG signals during a long-term EEG recording is inconvenient and uncomfortable for the subject. To remove ocular artifacts from EEG in brain-computer interfaces (BCIs), a method named spatial constraint independent component analysis based recursive least squares (SCICA-RLS) is proposed. The method consists of two stages. In the first stage, independent component analysis (ICA) is used to decompose multiple EEG channels into an equal number of independent components (ICs). Ocular ICs are identified by an automatic artifact detection method based on kurtosis. Then empirical mode decomposition (EMD) is employed to remove any cerebral activity from the identified ocular ICs to obtain exact artifact ICs. In the second stage, first, SCICA applies exact artifact ICs obtained in the first stage as a constraint to extract artifact ICs from the given EEG signal. These extracted ICs are called spatial constraint ICs (SC-ICs). Then the RLS based adaptive filter uses SC-ICs as reference signals to reduce interference, which avoids the need for parallel EOG recordings. In addition, the proposed method has the ability of fast computation as it is not necessary for SCICA to identify all ICs like ICA. Based on the EEG data recorded from seven subjects, the new approach can lead to average classification accuracies of 3.3% and 12.6% higher than those of the standard ICA and raw EEG, respectively. In addition, the proposed method has 83.5% and 83.8% reduction in time-consumption compared with the standard ICA and ICA-RLS, respectively, which demonstrates a better and faster OA reduction.

关键词： Ocular artifacts     Electroencephalogram (EEG)     Electrooculogram (EOG)     Brain-computer interface (BCI)     Spatial constraint independent component analysis based recursive least squares (SCICA-RLS)    

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A modified chronic ocular hypertension rat model for retinal ganglion cell neuroprotection

null

《医学前沿（英文）》 2013年 第7卷 第3期   页码 367-377 doi: 10.1007/s11684-013-0266-2

摘要：

This study aimed to modify a chronic ocular hypertension (OHT) rat model to screen for potential compounds to protect retinal ganglion cells (RGCs) from responding to increased intraocular pressure (IOP). A total of 266 rats were prepared and randomly grouped according to different time-points, namely, weeks 3, 8, 16, and 24. Rats were sedated and eye examination was performed to score as the corneal damage on a scale of 1 to 4. The OHT rat model was created via the injection of a hypertonic saline solution into the episcleral veins once weekly for two weeks. OHT was identified when the IOP at week 0 was≥6 mmHg than that at week -2 for the same eye. Viable RGCs were labeled by injecting 4% FluoroGold. Rats were sacrificed, and the eyes were enucleated and fixed. The fixed retinas were dissected to prepare flat whole-mounts. The viable RGCs were visualized and imaged. The IOP (meanβ±βSD) was calculated, and data were analyzed by the paired t-test and one-way ANOVA. The OHT model was created in 234 of 266 rats (87.97%), whereas 32 rats (12.03%) were removed from the study because of the absence of IOP elevation (11.28%) and/or corneal damage scores over 4 (0.75%). IOP was elevated by as much as 81.35% for 24 weeks. The average IOP was (16.68β±β0.98)βmmHg in non-OHT eyes (n = 234), but was (27.95±0.97)βmmHg in OHT eyes (n = 234). Viable RGCs in the OHT eyes were significantly decreased in a time-dependent manner by 29.41%, 38.24%, 55.32%, and 59.30% at weeks 3, 8, 16, and 24, respectively, as compared to viable RGCs in the non-OHT eyes (P<β0.05). The OHT model was successfully created in 88% of the rats. The IOP in the OHT eyes was elevated by approximately 81% for 24 weeks. The number of viable RGCs was decreased by 59% of the rats in a time-dependent manner. The modified OHT model may provide an effective and reliable method for screening drugs to protect RGCs from glaucoma.

关键词： chronic ocular hypertension     intraocular pressure     retinal ganglion cells     neuroprotection     glaucoma    

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Investigation on sampling artifacts of particle associated PAHs using ozone denuder systems

Kai LIU, Fengkui DUAN, Kebin HE, Yongliang MA, Yuan CHENG

《环境科学与工程前沿（英文）》 2014年 第8卷 第2期   页码 284-292 doi: 10.1007/s11783-013-0555-7

摘要： Polycyclic aromatic hydrocarbons (PAHs) are complex organic compounds which are identified as significant carcinogenic to human health. PAHs (mainly in particle phase) are susceptible to atmospheric oxidant gases, especially ozone, nitrogen oxides (NO ), hydroxyl radical (OH), and could be degraded on filters during sampling process, leading to an underestimation of ambient PAH concentrations. The goal of this work was to investigate particle associated PAHs sampling artifacts caused by ozone in summer of Beijing. Comparative sampling systems were operated simultaneously during the whole campaign, one with activated carbon ozone denuder, the other being set as conventional sampling system. Activated carbon denuder was testified to be highly efficient to eliminate ozone from air stream. In general, nine particle-bound PAHs observed from conventional sampler were all lower than those from ozone denuder system. The total PAHs (particle phase) concentration was averagely underestimated by 35.9% in conventional sampling procedure. Benzo[a]pyrene (BaP) had the highest percentage of mass loss. Ambient temperature was founded to have influences on PAHs sampling artifacts. High temperature can increase loss of particle associated PAHs during sampling.

关键词： particle associated polycyclic aromatic hydrocarbons (PAHs)     ozone     denuder     sampling artifacts    

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Behavioral methods for the functional assessment of hair cells in zebrafish

null

《医学前沿（英文）》 2017年 第11卷 第2期   页码 178-190 doi: 10.1007/s11684-017-0507-x

摘要：

Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafish displays a series of innate and robust behavior related to its auditory function. Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral tests, as follows: the startle response, the vestibular-ocular reflex, and rheotaxis. These tests are discussed in terms of their physiological characteristics, up-to-date technical development, and apparatus description. Test limitation and areas to improve are also introduced. Finally, we revealed the feasibility of these applications in zebrafish behavioral assessment and their potential in the high-throughput screening on hearing-related genes and drugs.

关键词： zebrafish (Danio rerio)     behavior     auditory     startle response     vestibular-ocular reflex     rheotaxis    

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通过分析目标制品间的紧密关系改进基于信息检索的需求追踪恢复 Research Articles

汪海娟1,沈国华1,2,3,黄志球1,2,3,俞垚慎1,陈凯1

《信息与电子工程前沿（英文）》 2021年 第22卷 第7期   页码 957-968 doi: 10.1631/FITEE.2000126

摘要： 需求追踪是一项重要且昂贵的任务，它创建了从需求到不同软件制品的追踪链。这些追踪链可以帮助工程师节约软件维护时间并降低维护复杂性。信息检索技术在需求追踪中应用广泛。它使用软件制品之间的文本相似性来创建链接。然而，如果两个制品不共享或仅共享少量单词，信息检索性能可能非常差。已有一些方法通过考虑目标制品之间的关系来增强信息检索，但它们仅限于代码，而无法应用于其他类型的目标制品。为克服这一局限，本文提出一种将信息检索方法与目标制品间的紧密关系相结合的自动化方法。具体地，我们增加了对目标制品间紧密关系的考虑，而不仅仅是从需求到目标制品的文本匹配。此外，在考虑目标制品间的关系时，该方法并不局限于目标制品的类型。我们在5个公共数据集上进行了实验，并考虑了需求和不同类型的软件制品之间的追踪链。结果表明，在相同的查全率下，5个数据集的查准率较之基线方法分别提高40%、8%、20%、4%和6%。5个数据集的查准率平均提高15.6%，这表明在相同条件下，本文所提方法优于基线方法。

关键词： 需求追踪；信息检索；紧密关系；目标制品    

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标题 作者 时间 类型 操作

Fast removal of ocular artifacts from electroencephalogram signals using spatial constraint independent

Bang-hua YANG,Liang-fei HE,Lin LIN,Qian WANG

期刊论文

A modified chronic ocular hypertension rat model for retinal ganglion cell neuroprotection

null

期刊论文

Investigation on sampling artifacts of particle associated PAHs using ozone denuder systems

Kai LIU, Fengkui DUAN, Kebin HE, Yongliang MA, Yuan CHENG

期刊论文

Behavioral methods for the functional assessment of hair cells in zebrafish

null

期刊论文

通过分析目标制品间的紧密关系改进基于信息检索的需求追踪恢复

汪海娟1,沈国华1,2,3,黄志球1,2,3,俞垚慎1,陈凯1

期刊论文